Made in JAPAN
Essence 8ml*4
Released on September 1, 2026
This is the pinnacle*3 serum in the history of the episteme brand, featuring a new formulation that combines the proprietary ingredient "Stem CM"*1 with "Stem EV Complex"*2—a moisturizing complex developed by leveraging Rohto Pharmaceutical's data science expertise. It targets the very source*4 of skin firmness, leading to a complexion that is deeply hydrated and brimming with resilience.
*1: Hydrolyzed human adipose-derived mesenchymal cell conditioned media (moisturizing ingredient) *2: Bitter orange peel extract, mandarin orange peel extract (all moisturizing ingredients) *3: Within the episteme brand *4: Stratum corneum
Key Ingredients
Stem CM*1, Stem EV Complex*2, Stem S Complex*3, Vitalize Complex*4, AG Deep Clear Complex*5
*1: Hydrolyzed human adipose-derived mesenchymal cell conditioned media (moisturizing ingredient) *2: Bitter orange peel extract, mandarin orange peel extract (all moisturizing ingredients)
*3: Caprooyl tetrapeptide-3, copper tripeptide-1, collagen (all moisturizing ingredients) *4: Soybean sprout extract, oligopeptide-24 (all moisturizing ingredients)
*5: Japanese plum (Prunus mume) fruit extract, edelweiss flower/leaf extract (all moisturizing ingredients)
Episteme is manufactured by ROHTO Pharmaceutical.
Rohto Pharmaceutical Co., Ltd.: https://en.wikipedia.org/wiki/Rohto_Pharmaceutical