POLA Wrinkle Shot Medical Serum N 20g
POLA Wrinkle Shot Medical Serum N 20g
POLA Wrinkle Shot Medical Serum N 20g
POLA Wrinkle Shot Medical Serum N 20g
POLA Wrinkle Shot Medical Serum N 20g
POLA Wrinkle Shot Medical Serum N 20g
POLA Wrinkle Shot Medical Serum N 20g
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POLA Wrinkle Shot Medical Serum N 20g

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¥17,486
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¥17,486
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Made in JAPAN
20g

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January 01, 2021 Upgraded
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Quasi-drugs

Fragrance free
Color free

World-first discovery on mechanism of wrinkles

Allergy tested (This does not guarantee that all users will not have allergic reaction)

Product Features
Wrinkle-Improving Mechanism That Inhibits Deterioration of the Dermis Components

The primary cause of dermal wrinkles*3 is the excessive deterioration of collagen and other dermis components. NEI-L1*4 inhibits the activity of neutrophil elastase, and suppresses the excessive deterioration of the dermis components.

A Dynamism Delivery Formulation containing oils with ductility, allowing the formula to spread dynamically on the skin
Uses small-sized, low-viscosity oils that spread to every corner of the skin.
As NEI-L1 has excellent affinity with water, we have developed an original formulation that stays stable when adding water and water-soluble components.
For this renewal, we have succeeded in adding three new ingredients. The water-soluble/oil-insoluble characteristics of NEI-L1 have been used to create a formula with other compatible ingredients.

“NEI-L1” is a quasi-drug active ingredient unique to POLA, found out of approximately 5,400 types of ingredients.
“NEI-L1” is a quasi-drug active ingredient that inhibits neutrophil elastase.
NEI-L1 is a component created from four amino acid derivatives that suppresses the activity of neutrophil elastase for wrinkle improvement.
It corrects the balance of dermis component generation and degradation for wrinkle improvement.


Once again, POLA is driving the evolution of wrinkle elimination.*
We want to help people around the world who worry about their wrinkles. 
From this strong conviction, in 2017 POLA introduced WRINKLE SHOT*, the first wrinkle-improving cosmetic product for medical use in Japan.

The door was opened on improving wrinkles, and several brands were born.
Even so, we won’t stop evolving.

We are a pioneer in the field of wrinkle improvement.
One area that continues to be a focus of our unique research is the individual differences in how wrinkles improve. Through an analysis of comments from 1.10 million people, we have discovered even more truths about wrinkles.

Consider the 3D dynamism theory that POLA has established.
We took aim at one of the causes behind wrinkles, and found that wrinkles could be improved by using the active ingredient NEI-L1* to penetrate deep into the dermis.

We don’t want to give up on wrinkles.
POLA won’t stop as long as there are others who share this view.
We now begin the second chapter of our journey towards the improvement of wrinkles.



Cosmetics and quasi-drugs categories

In Japan, the Japanese Ministry of Health, Labour & Welfare classifies the beauty products under 2 categories: cosmetics and quasi-drugs. Quasi-drugs, in opposite to cosmetics, are medicated, have a mild pharmacologic effect and include active ingredients. If the product is approved as a quasi-drug by the ministry, the manufacturer is allowed to actually claim the effectiveness of the product.